Midkine [Articles - Original research articles as references]

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Original research articles as references

Kadomatsu, K., Tomomura, M. and Muramatsu, T. (1988) cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Biochem. Biophys. Res. Commun. 151, 1312-1318. [PMID: 3355557]
Vigny, M., Raulais, D., Puzenat, N., Duprez, D., Hartmann, M. P., Jeanny, J. C., and Courtois, Y. (1989) Identification of a new heparin-binding protein localized within chick basement membranes. Eur. J. Biochem. 186, 733-740. [PMID: 2558016]
Kadomatsu, K., Huang, R.. P., Suganuma, T., Murata, F. and Muramatsu, T. (1990) A retinoic acid responsive gene MK found in the teratocarcinoma system is expressed in spatially and temporally controlled manner during mouse embryogenesis. J. Cell Biol. 110, 607-616. [PMID: 1689730]
Tomomura, M., Kadomatsu, K., Matsubara, S. and Muramatsu, T. (1990) A retinoic acid-responsive gene, MK, found in the teratocarcinoma system. Heterogeneity of the transcript and the nature of the translation product. J. Biol. Chem. 265, 10765-10770. [PMID: 2355021]
Merenmies, J. and Rauvala, H. (1990) Molecular cloning of the 18-kDa growth-associated protein of developing brain. J. Biol. Chem. 265, 16721-16724. [PMID: 2170351]
Li, Y. S., Milner, P. G., Chauhan, A. K., Watson, M. A., Hoffman, R. M., Kodner, C. M., Milbrandt, J. and Deuel, T. F. (1990) Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. Science 250, 1690-1694. [PMID: 2270483]
Matsubara, S., Tomomura, M., Kadomatsu, K. and Muramatsu, T. (1990) Structure of a retinoic acid-responsive gene, MK, which is transiently activated during the differentiation of embryonal carcinoma cells and the mid-gestation period of mouse embryogenesis. J. Biol. Chem. 265, 9441-9443. [PMID: 2345177]
Tomomura, M., Kadomatsu, K., Nakamoto, M., Muramatsu, H., Kondoh, H., Imagawa, K. and Muramatsu, T. (1990) A retinoic acid responsive gene, MK, produces a secreted protein with heparin binding activity. Biochem. Biophys. Res. Commun. 171, 603-609. [PMID: 2403350]
Muramatsu, H. and Muramatsu, T. (1991) Purification of recombinant midkine and examination of its biological activities: functional comparison of new heparin binding factors. Biochem. Biophys. Res. Commun. 177, 652-658. [PMID: 2049087]
Tsutsui, J., Uehara, K., Kadomatsu, K., Matsubara, S. and Muramatsu, T. (1991) A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse. Biochem. Biophys. Res. Commun. 176, 792-797. [PMID: 2025291]
Raulais, D., Lagente-Chevallier, O., Guettet, C., Duprez, D., Courtois, Y. and Vigny, M. (1991) A new heparin-binding protein regulated by retinoic acid from chick embryos. Biochem. Biophys. Res. Commun. 174, 708-715 [PMID: 1993066]
Simon-Chazottes, D., Matsubara, S., Miyauchi, T., Muramatsu, T. and Guenet, J. L. (1992) Chromosomal localization of two cell-surface associated molecules of potential importance in development: midkine (Mdk) and basigin (Bsg). Mamm. Genome 2, 269-271. [PMID: 1347477]
Nurcombe, V., Fraser, N., Herlaar, E. and Heath, J.K. (1992) MK: a pluripotential embryonic stem-cell-derived neuroregulatory factor. Development. 116, 1175-1183. [PMID: 1295735]
Tsutsui, J., Kadomatsu, K., Matsubara, S., Nakagawara, A., Hamanoue, M., Takao, S., Shimazu, H., Ohi, Y. and Muramatsu, T. (1993) A new family of heparin-binding growth differentiation factors : increased midkine expression in Wilms' tumor and other human carcinomas. Cancer Res. 53, 1281-1285. [PMID: 8383007]
Michikawa, M., Kikuchi, S., Muramatsu, H., Muramatsu, T. and Kim, S.U. (1993) Retinoic acid responsive gene product, midkine (MK), has neurotrophic functions for mouse spinal cord and dorsal root ganglion neurons in culture. J. Neurosci. Res., 35, 530-539. [PMID: 8377224]
Satoh, J., Muramatsu, H., Moretto, G., Muramatsu, T., Chang, H.J., Kim, S.T., Cho, J.M. and Kim, S.U. (1993) Midkine that promotes survival of human neurons is produced by fetal human astrocytes in culture. Dev. Brain Res. 75, 201-205. [PMID: 8261612]
Yasuhara, O., Muramatsu, H., Kim, S. U., Muramatsu, T., Maruta, H. and McGeer, P. L. (1993) Midkine, a novel neurotrophic factor, is present in senile plaques of Alzheimer disease. Biochem. Biophys. Res. Commun. 192, 246-251. [PMID: 8476427]
Muramatsu, H., Shirahama, H., Yonezawa, S., Maruta, H. and Muramatsu, T.(1993) Midkine (MK), a retinoic acid-inducible growth/differentiation factor : immunochemical evidence for the function and distribution. Dev. Biol. 159, 392-402. [PMID: 8405666]
Fabri, L., Maruta, H., Muramatsu, H., Muramatsu, T., Simpson, R.J., Burgess, A.W. and Nice, E.C. (1993) Structural characterization of native and recombinant forms of the neurotrophic cytokine MK. J. Chromatog. 646, 213-226. [PMID: 8408430]
Uehara, K., Matsubara, S., Kadomatsu, K., Tsutsui, J. and Muramatsu, T. (1992) Genomic structure of human midkine (MK), a retinoic acid-responsive growth / differentiation factor. J. Biochem. 111, 563-567. [PMID: 1639750]
Kaname, T., Kuwano, A., Murano, I., Uehara, K., Muramatsu, T. and Kajii, T. (1993) Midkine gene (MDK), a gene for prenatal differentiation and neuroregulation, maps to band 11p11.2 by fluorescence in situ hybridization. Genomics 17, 514-515. [PMID: 8406506]
Garver, R. I., Jr., Chan, C. S. and Milner, P. G. (1993) Reciprocal expression of pleiotrophin and midkine in normal versus malignant lung tissues. Am. J. Respir. Cell Mol. Biol. 9, 463-466. [PMID: 8217186]
Garver, R. I. Jr., Radford, D. M., Donis-Keller, H., Wick, M. R. and Milner, P. G. (1994) Midkine and pleiotrophin expression in normal and malignant breast tissue. Cancer 74, 1584-1590. [PMID: 7520350]
Muramatsu, H., Inui, T., Kimura, T., Sakakibara, S., Song, X., Murata, H. and Muramatsu, T. (1994) Localization of heparin-binding, neurite outgrowth and antigenic regions in midkine molecule. Biochem. Biophys. Res. Commun. 203, 1131-1139. [PMID: 8093031]
Matsubara, S., Take, M., Pedraza, C. and Muramatsu, T. (1994) Mapping and characterization of a retinoic acid-responsive enhancer of midkine, a novel heparin binding growth / differentiation factor with neurotrophic activity. J. Biochem. 115, 1088-1096. [PMID: 7982887]
Unoki, K., Ohba, N., Arimura, H., Muramatsu, H. and Muramatsu, T. (1994) Rescue of photoreceptors from the damaging effects of constant light by midkine , a retinoic acid responsive gene product. Invest. Ophthalmol. Vis. Sci. 35, 4063-4068. [PMID: 7960588]
Take, M., Tsutsui, J., Obama, H., Ozawa, M., Nakayama, T., Maruyama, I., Arima, T. and Muramatsu, T. (1994) Identification of nucleolin as a binding protein for midkine (MK) and heparin-binding growth-associated molecule (HB-GAM). J.Biochem. 116, 1063-1068. [PMID: 7896734]
Matsumoto, K., Wanaka, A., Takatsuji, K., Muramatsu, H., Muramatsu, T. and Tohyama, M. (1994) A novel family of heparin-binding growth factors, pleiotrophin and midkine, is expressed in the developing rat cerebral cortex. Dev. Brain Res. 79, 229-241. [PMID: 7955321]
Matsumoto, K., Wanaka, A., Mori, T., Taguchi, A., Ishii, N., Muramatsu, H., Muramatsu, T. and Tohyama, M. (1994) Localization of pleiotrophin and midkine in the postnatal developing cerebellum. Neurosci. Lett. 179, 216-220. [PMID: 7824199]
Kojima, S., Muramatsu, H., Amanuma, H., and Muramatsu, T. (1995) Midkine enhances fibrinolytic activity of bovine endothelial cells. J. Biol. Chem. 270, 9590-9596 [PMID: 7721890]
Mitsiadis, T.A., Muramatsu, T., Muramatsu, H. and Thesleff, I. (1995) Midkine (MK), a heparin-binding growth/differentiation factor, is regulated by retinoic acid and epithelial-mesenchymal interactions in the developing mouse tooth, and affects cell proliferation and morphogenesis. J. Cell Biol. 129, 267-281. [PMID: 7698992]
Mitsiadis, T.A., Salmivirta, M., Muramatsu, T., Muramatsu, H., Rauvala, H., Lehtonen, E., Jalkanen, M. and Thesleff, I. (1995) Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis, Development 121, 37-51. [PMID: 7867507]
Nakagawara, A., Milbrandt, J., Muramatsu, T., Deuel, T.F., Zhao, H., Cnaan, A. and Brodeur, G.M. (1995) Differential expression of pleiotrophin and midkine in advanced neuroblastomas. Cancer Res. 55, 1792-1797. [PMID: 7712489]
Aridome, K., Tsutsui, J., Takao, S., Kadomatsu, K., Ozawa, M., Aikou, T. and Muramatsu, T.(1995) Increased midkine gene expression in human gastrointestinal cancers. Jap. J. Cancer Res. 86, 655-661. [PMID: 7559083]
Yoshida, Y., Goto, M., Tsutsui, J., Ozawa, M., Sato, E., Osame, M. and Muramatsu, T. (1995) Midkine is present in the early stage of cerebral infarct. Dev. Brain Res. 85, 25-30. [PMID: 7781164]
Obama, H., Tsutsui, J., Ozawa, M., Yoshida, H., Osame, M. and Muramatsu, T. (1995) Midkine (MK) and pleiotrophin (PTN) expression in extraembryonic tissues, amniotic fluid and cerebrospinal fluid during mouse embryogenesis. J. Biochem. 118, 88-93. [PMID: 8537330]
Kojima, T., Katsumi, A., Yamazaki, T., Muramatsu, T., Nagasaka, T., Ohsumi, K. and Saito, H. (1996) Human ryudocan from endothelial-like cells binds basic fibroblast growth factor, midkine, and tissue factor pathway inhibitor. J. Biol. Chem. 271, 5914-5920. [PMID: 8621465]
Kaneda, N., Talukder, A.H., Ishihara, M., Hara, S., Yoshida, K. and Muramatsu, T. (1996) Structural characteristics of heparin-like domain required for interaction of midkine with embryonic neurons. Biochem. Biophys. Res. Commun. 220, 108-112. [PMID: 8602827]
Inui, T., Bodi, J., Kubo, S., Nishio, H., Kimura, T., Kojima, S., Maruta, H., Muramatsu, T. and Sakakibara, S. (1996) Solution synthesis of human midkine, a novel heparin binding neurotrophic factor consisting of 121 amino acid residues with five disulphide bonds, J. Peptide Sci. 2, 28-39. [PMID: 9225243]
Adachi, Y., Matsubara, S., Pedraza, C., Ozawa, M., Tsutsui, J., Takamatsu, H., Noguchi, H., Akiyama, T. and Muramatsu, T. (1996) Midkine as a novel target gene for the Wilms' tumor suppressor gene (WT1). Oncogene 13, 2197-2203. [PMID: 8950987]
Muramatsu, H., Song, X., Koide, N., Hada, H., Tsuji, T., Kadomatsu, K., Inui, T., Kimura, T., Sakakibara, S. and Muramatsu, T. (1996) Enzyme-linked immunoassay for midkine and its application to evaluation of midkine levels in developing mouse brain and in sera from patients with hepatocellular carcinomas. J. Biochem. 119, 1171-1175. [PMID: 8827454]
O'Brien, T., Cranston, D., Fuggle, S., Bicknell, R. and Harris, A.L. (1996) The angiogenic factor midkine is expressed in bladder cancer, and overexpression correlates with a poor outcome in patients with invasive cancers. Cancer Res. 56, 2515-2518. [PMID: 8653688]
Kaname, T., Kadomatsu, K., Aridome, K., Yamashita, S., Sakamoto, K., Ogawa, M., Muramatsu, T. and Yamamura, K. (1996) The expression of truncated MK in human tumors. Biochem. Biophys. Res. Commun. 219, 256-260. [PMID: 8619817]
Kadomatsu, K., Hagihara, M., Akhter, S., Fan, Q-W., Muramatsu, H. and Muramatsu, T. (1997) Midkine induces the transformation of NIH3T3 cells. Brit. J. Cancer 75, 354-359. [PMID: 9020479]
Kojima, S., Inui, T., Muramatsu, H., Suzuki, Y., Kadomatsu, K., Yoshizawa, M., Hirose, S., Kimura, T., Sakakibara, S. and Muramatsu, T. (1997) Dimerization of midkine by tissue transglutaminase and its functional implication. J. Biol. Chem. 272, 9410-9416. [PMID: 9083079]
Zhou, H., Muramatsu, T., Halfter, W., Tsim, K. W. K. and Peng H. B. (1997) A role of midkine in the development of the neuromuscular junction. Mol. Cell. Neurosci. 10, 56-70. [PMID: 9361288]
Takada, T., Toriyama, K., Muramatsu, H., Song, X. J., Torii, S. and Muramatsu, T. (1997) Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: chemotactic activity to neutrophils and association with inflammatory synovitis. J. Biochem. 122, 453-458. [PMID: 9378726]
Iwasaki, W., Nagata, K., Hatanaka, H., Inui, T., Kimura, T., Muramatsu, T., Yoshida, K., Tasumi, M. and Inagaki, F. (1997) Solution structure of midkine, a new heparin-binding growth factor. EMBO J. 16, 6936-6946. [PMID: 9384573]
Nakanishi, T., Kadomatsu, K., Okamoto, T., Ichihara-Tanaka, K., Kojima, T., Saito, H., Tomoda, Y. and Muramatsu, T. (1997) Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine. J. Biochem. 121, 197-205. [PMID: 9089390]
Asai, T., Watanabe, K., Ichihara-Tanaka, K., Kaneda, N., Kojima, S., Iguchi, A., Inagaki, F. and Muramatsu, T. (1997) Identification of heparin-binding sites in midkine and their role in neurite-promotion. Biochem. Biophys. Res. Commun. 236, 66-70. [PMID: 9223427]
Choudhuri R., Zhang, H. T., Donnini, S., Ziche, M. and Bicknell, R. (1997) An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis. Cancer Res. 57, 1814-1819. [PMID: 9135027]
Sun X.-Z., Inoue, M., Fukui, Y., Hisano, S., Sawada, K., Muramatsu, H. and Muramatsu, T. (1997) An immunohistochemical study of radial glial cells in the mouse brain prenatally exposed to γ-irradiation. J. Neuropathol. Exp. Neurol. 56, 1339-1348. [PMID: 9413282]
Mishima, K., Asai, A., Kadomatsu, K., Ino, Y., Nomura, K., Narita, Y., Muramatsu, T. and Kurino, T. (1997) Increased expression of midkine during the progression of human astrocytomas. Neurosci. Lett. 233, 29-32. [PMID: 9324232]
Obama, H., Biro, S., Tashiro, T., Tsutsui, J., Ozawa, M., Yoshida, H., Tanaka, H. and Muramatsu, T. (1998) Midkine expression in the heart is induced by myocardial infarction. Anticancer Res. 18, 145-152. [PMID: 9568069]
Nakamura, E., Kadomatsu, K., Yuasa, S., Muramatsu, H., Mamiya, T., Nabeshima, T., Fan, Q.W., Ishiguro, K., Igakura, T., Matsubara, S., Kaname, T., Horiba, M., Saito, H. and Muramatsu, T. (1998) Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour. Genes Cells 3, 811-822. [PMID: 10096022]
Yokota, C., Takahashi, S., Eisaki, A., Asashima, M., Akhter, S., Muramatsu, T. and Kadomatsu, K. (1998) Midkine counteracts the activin signal in mesoderm induction and promotes neural formation. J. Biochem. 123, 339-346. [PMID: 9538212]
Yu, G.S., Hu, J. and Nakagawa, H. (1998) Inhibition of b-amyloid cytotoxicity by midkine. Neurosci. Lett. 254, 125-128. [PMID: 10214973]
Maeda, N., Ichihara-Tanaka, K., Kimura, T., Kadomatsu, K., Muramatsu, T. and Noda, M. (1999) A receptor-like protein -tyrosine phosphatase PTPζ/RPTPβ binds a heparin- binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPζ. J. Biol. Chem. 274, 12474-12479. [PMID: 10212223]
Ye, C., Qi, M., Fan, Q.-W., Ito, K., Akiyama, S., Kasai, Y., Matsuyama, M., Muramatsu, T. and Kadomatsu, K. (1999) Expression of midkine in the early stage of carcinogenesis in human colorectal cancer. Brit. J. Cancer 79, 179-184. [PMID: 10408712]
Konishi, N., Nakamura, M., Nakaoka, S., Hiasa, Y., Cho, M., Uemura, H., Hirao, Y., Muramatsu, T. and Kadomatsu, K. (1999) Immunohistochemical analysis of midkine expression in human prostate carcinoma. Oncology 57,253-257. [PMID: 10545795]
Owada, K., Sanjo, N., Kobayashi, T., Mizusawa, H., Muramatsu, H., Muramatsu, T. and Michikawa, M. (1999) Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons. J. Neurochem. 73, 2084-2092. [PMID: 10537068]
Ohta, S., Muramatsu, H., Senda, T., Zou, K., Iwata, H. and Muramatsu, T. (1999) Midkine is expressed during repair of bone fracture and promotes chondrogenesis. J. Bone Miner. Res. 14, 1132-1144. [PMID: 10404013]
Kato, S., Ishihara, K., Shinozawa, T., Yamaguchi, H., Asano, Y., Saito, M., Kato, M., Terada, T., Awaya, A., Hirano, A., Dickson, D.W., Yen, S.H. and Ohama, E. (1999) Monoclonal antibody to human midkine reveals increased midkine expression in human brain tumors. J. Neuropathol. Exp. Neurol. 58, 430-441. [PMID: 10331431]
Ikematsu, S., Yano, A., Aridome, K., Kikuchi, M., Kumai, H., Nagano, H., Okamoto, K., Oda, M., Sakuma, S., Aikou, T., Muramatsu, H., Kadomatsu, K. and Muramatsu, T. (2000) Serum midkine levels are increased in patients with various types of carcinomas. Brit. J. Cancer. 83, 701-706. [PMID: 10952771]
Zou, K., Muramatsu, H., Ikematsu, S., Sakuma, S., Salama, R.H., Shinomura, T., Kimata, K. and Muramatsu, T. (2000) A heparin-binding growth factor, midkine, binds to a chondroitin sulfate proteoglycan, PG-M/versican. Eur. J. Biochem. 267, 4046-4053. [PMID: 10866805]
Ueoka, C., Kaneda, N., Okazaki, I., Nadanaka, S., Muramatsu, T., and Sugahara, K. (2000) Neuronal cell adhesion mediated by the heparin-binding neuroregulatory factor, midkine, is specifically inhibited by chondroitin sulfate E. Structural and functional implication of the oversulfated chondroitin sulfate. J. Biol. Chem. 275, 37407-37413. [PMID: 10978312]
Horiba, M., Kadomatsu, K., Nakamura, E., Muramatsu, H., Ikematsu, S., Sakuma, S., Hayashi, K., Yuzawa, Y., Matsuo, S., Kuzuya, M., Kaname, T., Hirai, M., Saito, H. and Muramatsu, T. (2000) Neointima formation in a restenosis model is suppressed in midkine-deficient mice. J. Clin. Invest. 105, 489-495. [PMID: 10683378]
Kurosawa, N., Kadomatsu, K., Ikematsu, S., Sakuma, S., Kimura, T. and Muramatsu, T. (2000) Midkine binds specifically to sulfatide: the role of sulfatide in cell attachment to midkine-coated surfaces. Eur. J. Biochem. 267, 344-351. [PMID: 10632704]
Muramatsu, H., Zou, K., Sakaguchi, N., Ikematsu, S., Sakuma, S. and Muramatsu, T. (2000) LDL-receptor related protein as a component of the midkine receptor. Biochem. Biophys. Res. Commun. 270, 936-941. [PMID: 10772929]
Ikeda, S., Ichihara-Tanaka, K., Azuma, T., Muramatsu, T. and Yamada, M. (2000) Effects of midkine during in vitro maturation of bovine oocytes on subsequent developmental competence. Biol. Reprod. 63, 1067-1074. [PMID: 10993828]
Adachi, Y., Reynolds, P. N., Yamamoto, M., Grizzle, W. E., Overturf, K., Matsubara, S., Muramatsu, T. and Curiel, D. T. (2000) Midkine promoter-based adenoviral vector gene delivery for pediatric solid tumors. Cancer Res. 60, 4305-4310. [PMID: 10969765]
Kato, M., Maeta, H., Kato, S., Shinozawa, T., and Terada, T. (2000) Immunohistochemical and in situ hybridization analyses of midkine expression in thyroid papillary carcinoma. Mod. Pathol. 13, 1060-1065. [PMID: 11048798]
Sumi, Y., Muramatsu, H., Hata, K., Ueda, M. and Muramatsu, T. (2000) Midkine enhances early stages of collagen gel contraction. J. Biochem. 127, 247-251. [PMID: 10731691]
Qi, M., Ikematsu, S., Ichihara-Tanaka, K., Sakuma, S. Muramatsu, T. and Kadomatsu, K. (2000) Midkine rescues Wilmsﾕ tumor cells from cisplatin-induced apoptosis: regulation of Bcl-2 expression by midkine. J. Biochem. 127,269-277. [PMID: 10731694]
Adachi, Y., Reynolds, P. N., Yamamoto, M., Wang, M., Takayama, K., Matsubara, S., Muramatsu, T. and Curiel, D. T. (2001) A midkine promoter-based conditionally replicative adenovirus for treatment of pediatric solid tumors and bone marrow tumor purging. Cancer Res. 61,7882-7888. [PMID: 11691808]
Miyauchi, M., Yoshida, Y., Tada, Y., Narita, M., Maeda, T., Bahar, R., Kadomatsu, K., Muramatsu, T., Matsubara, S., Nakagawara, A., Sakiyama, S. and Tagawa, M. (2001) Expression of herpes simplex virus-thymidine kinase gene controlled by a promoter region of the midkine gene confers selective cytotoxicity to ganciclovir in human carcinoma cells. Int. J. Cancer 91, 723-727. [PMID: 11267987]
Callebaut, C., Nisole, S., Briand, J. P., Krust, B. and Hovanessian, A. G. (2001) Inhibition of HIV infection by the cytokine midkine. Virology 281, 248-264. [PMID: 11277697]
Winkler, C. and Moon, R. T. (2001) Zebrafish mdk2, a novel secreted midkine, participates in posterior neurogenesis. Dev. Biol. 229, 102-118. [PMID: 11133157]
Kurosawa, N., Chen, G., Kadomatsu, K., Ikematsu, S., Sakuma S. and Muramatsu, T. (2001) Glypican-2 binds to midkine: The role of glypican-2 in neuronal cell adhesion and neurite outgrowth. Glycoconj. J. 18, 499-507. [PMID: 12084985]
Sato, W., Kadomatsu, K., Yuzawa, Y., Muramatsu, H., Hotta, N., Matsuo, S. and Muramatsu T. (2001) Midkine is involved in neutrophil infiltration into the tubulointerstitium in ischemic renal injury. J. Immunol. 167, 3463-3469. [PMID: 11544339]
Mashour, G. A., Ratner, N., Khan, G. A., Wang, H. L., Martuza, R. L. and Kurtz, A. (2001) The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells. Oncogene 20, 97-105. [PMID: 11244508]
Takei, Y., Kadomatsu, K., Matsuo, S., Itoh, H., Nakazawa, K., Kubota,S. and Muramatsu, T. (2001) Antisense oligodeoxynucleotide targeted to midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells. Cancer Res. 61, 8486-8491. [PMID: 11731432]
Salama, R. H. M., Muramatsu, H., Zou, K., Inui, T., Kimura, T. and Muramatsu, T. (2001) Midkine binds to 37-kDa laminin　binding protein precursor, leading to nuclear transport of the complex. Exp. Cell Res. 270,13-20. [PMID: 11597123]
Qi, M., Ikematsu, S., Maeda, N., Ichihara-Tanaka, K., Sakuma, S., Noda, M., Muramatsu, T. and Kadomatsu, K. (2001) Haptotactic migration induced by midkine: Involvement of protein-tyrosine phosphatasez, mitogen-activated protein kinase and phosphatidylinositol 3-kinase. J. Biol. Chem. 276, 15868-15875. [PMID: 11340082]
Yoshida, Y., Ikematsu, S., Moritoyo, T., Goto, M., Tsutsui, J., Sakuma, S., Osame, M. and Muramastu, T. (2001) Intraventricular administration of the neurotrophic factor midkine ameliorates hippocampal delayed neuronal death following transient forebrain ischemia in gerbils. Brain Res. 894, 46-55 [PMID: 112459814]
Shibata, Y., Muramatsu, T., Hirai, M., Inui, T., Kimura, T., Saito, H., McCormick, L.M., Bu, G. and Kadomatsu, K. (2002) Nuclear targeting by the growth factor midkine. Mol. Cell. Biol. 22, 6788-6796. [PMID: 12215536]
Sumi, Y., Muramatsu, H., Takei, Y., Hata, K., Ueda, M. and Muramatsu, T. (2002) Midkine, a heparin-binding growth factor promotes growth and glycosaminoglycan synthesis of endothelial cells through its action on smooth muscle cells in an artificial blood vessel model. J. Cell Sci.115, 2659-2667. [PMID: 12077357]
Stoica, G.E., Kuo, A., Powers, C., Bowden, E.T., Sale, E.B., Riegel, A.T. and Wellstein A. (2002) Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types. J. Biol. Chem. 277, 35990-35998. [PMID: 12122009]
Ikematsu, S., Nakagawara, A., Nakamura, Y., Sakuma, S., Wakai, K., Muramatsu, T. and Kadomatsu, K. (2003) Correlation of elevated level of blood midkine with poor prognostic factors of human neuroblastomas. Br. J. Cancer 88, 1522-1526. [PMID: 12771916]
Shimada, H., Nabeya, Y., Tagawa, M., Okazumi, S., Matsubara, H., Kadomatsu, K., Muramatsu,T., Ikematsu, S., Sakuma, S. and Ochiai, T.(2003) Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma. Cancer Sci. 94, 628-632. [PMID: 12841873]
Shimada, H., Nabeya, Y., Okazumi, S., Matsubara, H., Kadomatsu, K., Muramatsu, T., Ikematsu, S., Sakuma, S. and Ochiai, T. (2003) Increased serum midkine concentration as a possible tumor marker in patients with superficial esophageal cancer. Oncol. Rep. 10, 411-414. [PMID: 12579281]
Ikematsu, S., Okamoto, K., Yoshida, Y., Oda, M., Sugano-Nagano, H., Ashida, K., Kumai, H., Kadomatsu, K., Muramatsu, H., Muramatsu, T. and Sakuma, S. (2003) High levels of urinary midkine in various cancer patients. Biochem. Biophys. Res. Commun. 306, 329-332. [PMID: 12804566]
Winkler, C., Schafer, M., Duschl, J., Schartl, M. and Volff, J.N. (2003) Functional divergence of two zebrafish midkine growth factors following fish-specific gene duplication. Genome Res. 13, 1067-1081. [PMID: 12743018]
Tomizawa, M., Yu, L., Wada, A., Tamaoki, T., Kadomatsu, K., Muramatsu, T., Matsubara, S., Watanabe, K., Ebara, M., Saisho, H., Sakiyama, S. and Tagawa, M. (2003) A promoter region of the midkine gene that is frequently expressed in human hepatocellular carcinoma can activate a suicide gene as effectively as the alpha-fetoprotein promoter. Br. J. Cancer 89, 1086-1090. [PMID: 12966430]
Sakaguchi, N., Muramatsu, H., Ichihara-Tanaka, K., Maeda, N., Noda, M., Yamamoto,T., Michikawa, M., Ikematsu, S., Sakuma S. and Muramatsu, T. (2003) Receptor-type protein tyrosine phosphatase z as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons. Neurosci. Res. 45, 219-224 [PMID: 12573468]
Zou, P., Zou, K., Muramatsu, H., Ichihara-Tanaka, K., Habuchi, O., Ohtake, S., Ikematsu, S., Sakuma S. and Muramatsu, T. (2003) Glycosaminoglycan structures required for strong binding to midkine, a heparin binding growth factor. Glycobiology 13, 35-42. [PMID: 12634322]
Muramaki, M., Miyake, H., Hara, I., and Kamidono, S.(2003) Introduction of midkine gene into human bladder cancer cells enhances their malignant phenotype, but increases their sensitivity to antiangiogenic therapy. Clin, Cancer Res. 9, 152-160. [PMID: 14613994]
Tomizawa, M., Yu, L., Wada, A,, Tamaoki, T., Kadomatsu, K., Muramatsu, T., Matsubara, S., Watanabe, K., Ebara, M,, Saisho, H., Sakiyama, S., and Tagawa, M. (2003) A promoter region of the midkine gene that is frequently expressed in human hepatocellular carcinoma can activate a suicide gene as effectively as the a-fetoprotein promoter. Br. J. Cancer 89, 1086-1090. [PMID: 12966430]
Kang, H. C., Kim, I. J., Park, J. H., Shin, Y., Ku, J. L., Jung, M. S., Yoo, B. C., Kim, H. K., and Park, J. G. (2004) Identification of genes with differential expression in acquired drug-resistant gastric cancer cells using high-density oligonucleotide microarrays. Clin. Cancer Res. 10, 272-284. [PMID: 14734480]
Suzuki, N., Shibata, Y., Urano, T., Murohara, T., Muramatsu, T., and Kadomatsu, K. (2004) Proteasomal degradation of the nuclear targeting growth factor midkine. J. Biol. Chem. 279, 17785-17791. [PMID: 14970216]
Inoh, K., Muramatsu, H., Ochiai, K., Torii, S., and Muramatsu, T. (2004) Midkine, a heparin-binding cytokine, plays key roles in intraperitoneal adhesions. Biochem. Biophys. Res. Commun. 317, 108-113. [PMID: 15047154]
Nobata, S., Mogi, H., and Shinozawa, T. (2004) Exon skipping of midkine pre-mRNA is enhanced by intronic polymorphism in a colon cancer cell line. Cancer Lett. 207, 89-93. [PMID: 15050737]
Sakakima, H., Yoshida, Y., Muramatsu, T., Yone K, Goto, M., Ijiri, K., Izumo, S.. Traumatic injury-induced midkine expression in the adult rat spinal cord during the early stage. J. Neurotrauma. 21, 471-477. [PMID: 15115596]
Yu, L., Yamamoto, N., Kadomatsu, K, Muramatsu, T., Matsubara, S., Sakiyama, S., and Tagawa, M. (2004) Midkine promoter can mediate transcriptional activation of a fused suicide gene in a broader range of human breast cancer compared with c-erbB-2 promoter. Oncology 66, 143-149. [PMID: 15138367]
Maruyama, K., Muramatsu, H., Ishiguro, N., and Muramatsu, T.(2004) Midkine, a heparin-binding growth factor, is fundamentally involved in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 50, 1420-1429. [PMID: 15146411]
Ohuchida, T., Okamoto, K., Akahane, K., Higure, A., Todoroki, H., Abe, Y., Kikuchi, M., Ikematsu, S., Muramatsu T, and Itoh, H.(2004) Midkine protects hepatocellular carcinoma cells against TRAIL-mediated apoptosis through down-regulation of caspase-3 activity. Cancer 100, 2430-2436. [PMID: 15160348]
Reynolds, P. R., Mucenski, M. L., Le Cras, T. D., Nichols, W. C., and Whitsett, J. A.(2004) Midkine is regulated by hypoxia and causes pulmonary vascular remodeling. J. Biol. Chem. 279, 37124-37132. [PMID: 15197188]
Kohno, S., Nakagawa, K., Hamada, K., Harada, H., Yamasaki, K., Hashimoto, K., Tagawa, M., Nagato, S., Furukawa, K., and Ohnishi, T. (2004) Midkine promoter-based conditionally replicative adenovirus for malignant glioma therapy. Oncol. Rep. 12, 73-78. [PMID: 15201962]
Mashour, G. A., Driever, P, H., Hartmann, M., Drissel, S. N., Zhang, T., Scharf, B., Felderhoff-Muser, U., Sakuma, S., Friedrich, R. E., Martuza, R. L., Mautner V. F., and Kurtz, A. (2004) Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1. Clin. Cancer Res. 10, 5677-5683. [PMID: 15355893]
Muramatsu, H., Zou, P., Suzuki, H., Oda, Y., Chen, G.-Y., Sakaguchi, N., Sakuma, S., Maeda, N., Noda, M., Takada, Y., and Muramatsu, T. (2004) a4b1- and a6b1-Integrins are functional receptors for midkine, a heparin-binding growth factor. J. Cell Sci. 117, 5405-5415 [PMID: 15466886]
Kawai, H., Sato, W., Yuzawa, Y., Kosugi, T., Matsuo, S., Takei, Y., Kadomatsu, K., and Muramatsu, T. (2004). Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage. Am. J. Pathol., 165, 1603-1612 [PMID: 15509530]
Ochiai, K., Muramatsu, H., Yamamoto, S., Ando, H and Muramatsu, T. (2004) The role of midkine and pleiotrophin in liver regeneration. Liver Int. 24, 484-491. [PMID: 15482347]
Sakakima, H., Yoshida, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S. and Muramatsu, T. (2004) Midkine expression in rat spinal motor neurons following sciatic nerve injury. Brain Res. Dev. Brain Res. 153, 251-260. [PMID: 15527898]
Takei, Y., Kadomatsu, K., Yuasa, K., Sato, W. and Muramatsu, T. (2005) Morpholino antisense oligomer targeting human midkine: Its application for cancer therapy. Int. J. Cancer 114, 490-497. [PMID: 15578698]
Hayashi, K., Banno, H., Kadomatsu, K., Takei, Y., Komori, K. and Muramatsu, T. (2005) Antisense oligodeoxyribonucleotide as to the growth factor midkine suppresses neointima formation induced by balloon injury. Am. J. Physiol. Heart Circ. Physiol. 288, H2203-2209. [PMID: 15637123]
Takada, J., Ooboshi, H., Ago, T., Kitazono, T., Yao, H., Kadomatsu, K., Muramatsu, T., Ibayashi, S. and Iida, M. (2005) Postischemic gene transfer of midkine, a neurotrophic factor, protects against focal brain ischemia. Gene Ther. 12, 487-493. [PMID: 15703767]
Nobata, S., Shinozawa, T. and Sakanishi, A. (2005) Truncated midkine induces transformation of cultured cells and short latency of tumorigenesis in nude mice. Cancer Lett. 219, 83-89. [PMID: 15694667]
Hirota, Y., Osuga, Y., Koga, K., Yoshino, O., Hirata, T., Harada, M., Morimoto, C., Yano, T., Tsutsumi, O., Sakuma, S., Muramatsu,T. and Taketani,Y. (2005) Possible implication of midkine in the development of endometriosis. Hum. Reprod. 20, 1084-1089. [PMID: 15734764]
Sato, W., Takei, Y., Yuzawa,Y., Matsuo, S., Kadomatsu, K.and Muramatsu, T. (2005) Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion. Kidney Int. 67, 1330-1339. [PMID: 15780085]
Chen, Q., Yuan, Y., Lin, S., Chang, Y., Zhuo, X., Wei, W., Tao,P., Ruan, L., Li, Q. and Li, Z. (2005) Transiently truncated and differentially regulated expression of midkine during mouse embryogenesis. Biochem. Biophys. Res. Commun. 330, 1230-1236. [PMID: 15823575]
Schafer, M., Rembold, M., Wittbrodt, J., Schartl, M. and Winkler, C. (2005) Medial floor plate formation in zebrafish consists of two phases and requires trunk-derived Midkine-a. Genes Dev. 19, 897-902. [PMID: 15833916]
Salama, R. H., Muramatsu, H., Shimizu, E., Hashimoto, K., Watanabe, H., Komatsu, N., Okumura, N., Koike, K., Shinoda, N., Okada, S., Iyo, M. and Muramatsu, T. (2005) Increased midkine levels in sera from patients with Alzheimer’s disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 29, 611-616 [PMID: 15866365]
Mirkin, B. L., Clark, S., Zheng, X., Chu, F., White, B. D., Greene, M. and Rebbaa, A. (2005) Identification of midkine as a mediator for intercellular transfer of drug resistance. Oncogene. 24, 4965-4974. [PMID: 15897897]
Ezquerra, L., Herradon, G., Nguyen, T., Silos-Santiago, I. and Deuel, T. F.(2005) Midkine, a newly discovered regulator of the renin-angiotensin pathway in mouse aorta: significance of the pleiotrophin/midkine developmental gene family in angiotensin II signaling. Biochem. Biophys. Res. Commun. 333, 636-643. [PMID: 15979460]
Friedrich, C., Holtkamp, N., Cinatl, J. Jr, Sakuma, S., Mautner, V. F., Wellman, S., Michaelis, M., Henze, G., Kurtz, A., Driever, P. H. (2005) Overexpression of Midkine in malignant peripheral nerve sheath tumor cells inhibits apoptosis and increases angiogenic potency. Int. J. Oncol. 27, 1433-1440. [PMID: 16211240]
Englund, C., Birve, A., Falileeva, L., Grabbe, C. and Palmer, R.H. (2006) Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster. Dev. Genes Evol. 216, 10-18. [PMID: 16220264]
Salama, R. H., Muramatsu, H., Zou, P., Okayama, M. and Muramatsu, T. Midkine, a heparin-binding growth factor, produced by the host enhances metastasis of Lewis lung carcinoma cells. Cancer Lett. 233, 16-20.
Kosugi, T., Yuzawa, Y., Sato, W., Kawai, H., Matsuo, S., Takei, Y., Muramatsu, T., and Kadomatsu, K. (2006) Growth factor midkine is involved in the pathogenesis of diabetic nephropathy. Am. J. Pathol. 168, 9-19. [PMID: 16400005]
Zou, P., Muramatsu, H., Sone, M., Hayashi, H., Nakashima, T., and Muramatsu, T. (2006) Mice doubly deficient in the midkine and pleiotrophin genes exhibit deficits in the expression of β-tectorin gene and in auditory response. Lab. Invest. 86, 645-653. [PMID: 16619002]
Flatscher-Bader, T., and Wilce, P. A. (2006) Chronic smoking and alcoholism change expression of selective genes in the human prefrontal cortex. Alcohol Clin. Exp. Res. 30, 908-915. [PMID: 16634861]
Ezquerra, L., Herradon, G., Nguyen, T., Silos-Santiago, I., and Deuel, T. F. (2006) Midkine is a potent regulator of the catecholamine biosynthesis pathway in mouse aorta. Life Sci. 79, 1049-1055. [PMID: 16643958]
Takei, Y., Kadomatsu, K., Goto,T., and Muramatsu, T. (2006) Combinational antitumor effect of siRNA against midkine and paclitaxel on growth of human prostate cancer xenografts. Cancer. 107, 864-873. [PMID: 16832814]
Yuki, T., Ishihara, S., Rumi, M. A., Ortega-Cava, C. F., Kadowaki,Y., Kazumori, H., Ishimura, N., Amano, Y., Moriyama, N., and Kinoshita, Y. (2006) Increased expression of midkine in the rat colon during healing of experimental colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 291, G735-7343. [PMID: 16959957]
Banno, H., Takei, Y., Muramatsu, T., Komori, K., and Kadomatsu, K. (2006) Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts. J. Vasc, Surg. 44, 633-641. [PMID: 16950446]
Ichihara-Tanaka, K., Oohira, A., Rumsby, M., and Muramatsu, T. (2006) Neuroglycan C is a novel midkine receptor involved in process-elongation of oligodendroglial precursor-like cells. J. Biol. Chem. 281, 30857-30864. [PMID: 16901907]
Ishimoto, H., Muench, M. O., Higuchi, T., Minegishi, K., Tanaka, M., Yoshimura, Y., and Jaffe, R. B. (2006) Midkine, a heparin-binding growth factor, selectively stimulates proliferation of definitive zone cells of the human fetal adrenal gland. J. Clin. Endocrinol. Metab. 91, 4050-4056. [PMID: 16895951]
Kuo, A. H., Stoica, G. E., Riegel, A. T., and Wellstein, A. (2006) Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase. Oncogene. 26, 859-869. [PMID: 16878150]
Yuki, T., Ishihara, S., Rumi, M.A., Ortega-Cava, C.F., Kadowaki, Y., Kazumori, H., Ishimura, N., Amano, Y., Moriyama, N., and Kinoshita, Y. (2006) Increased expression of midkine in the rat colon during healing of experimental colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 291, G735-G743. [PMID: 16959957]
Sakakima, H., Kamizono, T., Matsuda, F., Izumo, K., Ijiri, K., and Yoshida, Y. (2006) Midkine and its receptor in regenerating rat skeletal muscle after bupivacaine injection. Acta Histochem. 108, 357-364. [PMID: 16965805]
Ikeda, S., Saeki, K., Imai, H., and Yamada, M. (2006) Abilities of cumulus and granulosa cells to enhance the developmental competence of bovine oocytes during in vitro maturation period are promoted by midkine; a possible implication of its apoptosis suppressing effects. Reproduction. 132, 549-557. [PMID: 17008466]
Horiba, M., Kadomatsu, K., Yasui, K., Lee, J.K., Takenaka, H., Sumida, A., Kamiya, K., Chen, S., Sakuma, S., Muramatsu, T., and Kodama, I.(2006) Midkine plays a protective role against cardiac ischemia/reperfusion injury through a reduction of apoptotic reaction.Circulation. 114, 1713-1720. [PMID: 17015789]
Yamamoto, H., Muramatsu, H., Nakanishi, T., Natori, Y., Sakuma, S., Ishiguro, N., and Muramatsu, T. (2006) Midkine as a molecular target: comparison of effects of chondroitin sulfate E and siRNA. Biochem. Biophys. Res. Commun. 351, 915-919. [PMID: 17094944]
Muramatsu, H., Zou, P., Kurosawa, N., Ichihara-Tanaka, K., Maruyama, K., Inoh, K., Sakai, T., Chen, L., Sato, M., and Muramatsu, T. (2006) Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors. Genes Cells. 11, 1405-1417. [PMID: 17121547]
Zou, P., Muramatsu, H., Miyata, T., and Muramatsu, T. (2006) Midkine, a heparin-binding growth factor, is expressed in neural precursor cells and promotes their growth. J. Neurochem. 99, 1470-1479. [PMID: 17230638]
Ezquerra, L., Perez-Garcia, C., Garrido, .E, Diez-Fernandez, C, Deuel, T.F., Alguacil, L.F., and Herradon, G. (2007) Morphine and yohimbine regulate midkine gene expression in the rat hippocampus. Eur. J. Pharmacol. 557, 147-150. [PMID: 17157293]
Kaifi, J.T., Fiegel, H.C., Rafnsdottir, S.L., Aridome, K., Schurr, P.G., Reichelt, U., Wachowiak, R., Kleinhans, H., Yekebas, E.F., Mann, O., Ichihara-Tanaka, K., Muramatsu, T., Kluth, D., Strate, T., and Izbicki, J.R. (2007) Midkine as a prognostic marker for gastrointestinal stromal tumors. J. Cancer Res. Clin. Oncol. 133, 431-435. [PMID: 17221186]
Tong, Y., Mentlein, R., Buhl, R., Hugo, H.H., Krause, J., Mehdorn, H.M., and Held-Feindt, J. (2007) Overexpression of midkine contributes to anti-apoptotic effects in human meningiomas. J. Neurochem. 100, 1097-1107. [PMID: 17181554]
Cernkovich, E.R., Deng, J., Hua, K., and Harp, J.B. (2007) Midkine is an autocrine activator of signal transducer and activator of transcription 3 in 3T3-L1 cells. Endocrinology. 148, 1598-1604. [PMID: 17204554]
Hidaka, H., Yagasaki, H., Takahashi, Y., Hama, A., Nishio, N., Tanaka, M., Yoshida, N., Villalobos, I.B., Wang, Y., Xu, Y., Horibe, K., Chen, S., Kadomatsu, K., and Kojima, S. (2007) Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia. Leuk. Res. 31, 1045-1051. [PMID: 17267033]
Marchionini, D.M., Lehrmann, E., Chu, Y., H,e B., Sortwell, C.E., Becker, K.G., Freed, W.J., Kordower, J.H., and Collier, T.J. (2007) Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease. Brain Res. 1147, 77-88. [PMID: 17368428]
Jia, H.L., Ye, Q.H., Qin, L.X., Budhu, A., Forgues, M., Chen, Y., Liu, Y.K., Sun, H.C., Wang, L., Lu, H.Z., Shen, F., Tang, Z.Y., and Wang, X.W. (2007) Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma. Clin. Cancer Res. 13, 1133-1139. [PMID: 17317821]
Dai, L.C., Wang, X., Yao, X., Min, L.S., Ping, J.L., and He, J.F. (2007) Antisense oligonucleotides targeting midkine inhibit tumor growth in an in situ human hepatocellular carcinoma model. Acta Pharmacol. Sin. 28, 453-458. [PMID: 17303011]
Tao, P., Xu, D., Lin, S., Ouyang, G.L., Chang, Y., Chen, Q., Yuan, Y., Zhuo, X., Luo, Q., Li, J., Li, B., Ruan, L., Li, Q., and Li, Z. (2007) Abnormal expression, highly efficient detection and novel truncations of midkine in human tumors, cancers and cell lines. Cancer Lett. 253, 60-67. [PMID: 17379400]
Tokuyama, W., Mikami, T., Fujiwara, M., Matsui, T., and Okayasu, I. (2007) Midkine expression in colorectal tumors: correlation with Ki-67 labeling in sporadic, but not ulcerative colitis-associated ones. Pathol. Int. 7, 260-267. [PMID: 17493173]
Maehara, H., Kaname, T., Yanagi, K., Hanzawa, H., Owan, I., Kinjou, T., Kadomatsu, K., Ikematsu, S., Iwamasa, T., Kanaya, F., and Naritomi, K. (2007) Midkine as a novel target for antibody therapy in osteosarcoma. Biochem. Biophys. Res. Commun. 358, 757-762. [PMID: 17506984]
Krzystek-Korpacka, M., Matusiewicz, M., Diakowska, D., Grabowski, K., Blachut, K., Kustrzeba-Wojcicka, I., and Banas, T. (2007) Serum midkine depends on lymph node involvement and correlates with circulating VEGF-C in oesophageal squamous cell carcinoma. Biomarkers 12, 403-413. [PMID: 17564845]
Maeda, S., Shinchi, H., Kurahara, H., Mataki, Y., Noma, H., Maemura, K., Aridome, K., Yokomine, T., Natsugoe, S., Aikou, T., and Takao, S. (2007) Clinical significance of midkine expression in pancreatic head carcinoma. Br. J. Cancer 97, 405-411. [PMID: 17622248]
Kosugi, T., Yuzawa, Y., Sato, W., Arata-Kawai, H., Suzuki, N., Kato, N., Matsuo, S., and Kadomatsu, K. (2007) Midkine is involved in tubulointerstitial inflammation associated with diabetic nephropathy. Lab. Invest. 87, 903-913. [PMID: 17607302]
Hanari, N., Matsubara, H., Hoshino, I., Akutsu, Y., Nishimori, T., Murakami, K., Sakata, H., Miyazawa, Y., and Ochiai, T. (2007) Combinatory gene therapy with electrotransfer of midkine promoter-HSV-TK and interleukin-21. Anticancer Res. 27, 2305-2310. [PMID: 17695518]
Toledano-Katchalski, H., Nir, R., Volohonsky, G., and Volk, T. (2007) Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading. Development 134, 3473-3481. [PMID: 17728343]
Hirota, Y., Osuga, Y., Nose, E., Koga, K., Yoshino, O., Hirata, T., Yano, T., Tsutsumi, O., Sakuma, S., Muramatsu, T., and Taketani, Y. (2007) The presence of midkine and its possible implication in human ovarian follicles. Am. J. Reprod. Immunol. 58, 367-373. [PMID: 17845207]
Terao, S., Shirakawa, T., Kubo, S, Bishunu, A., Lee, S.J., Goda, K., Tsukuda, M., Hamada, K., Tagawa, M., Takenaka, .A, Fujisawa, M., and Gotoh, A. (2007) Midkine promoter-based conditionally replicative adenovirus for targeting midkine-expressing human bladder cancer model. Urology, 70, 1009-1013. [PMID: 17919690]
Krzystek-Korpacka, M., Matusiewicz, M., Diakowska, D., Grabowski, K., Blachut, K., Kustrzeba-Wojcicka, I., and Banas, T. (2007) Impact of weight loss on circulating IL-1, IL-6, IL-8, TNF-alpha, VEGF-A, VEGF-C and midkine in gastroesophageal cancer patients. Clin. Biochem., 40, 1353-1360. [PMID: 17931612]
Chen, S., Bu, G., Takei, Y., Sakamoto, K., Ikematsu, S., Muramatsu, T., and Kadomatsu, K. (2007) Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells. J. Cell Sci., 120, 4009-4015. [PMID: 17971413]
Liedtke, D. and Winkler, C. (2008) Midkine-b regulates cell specification at the neural plate border in zebrafish. Dev Dyn. 237, 62-74. [PMID: 18058915]
Wang, J., Takeuchi, H., Sonobe, Y., Jin, S., Mizuno, T., Miyakawa, S. Fujiwara, M., Nakamura, Y., Kato, T., Muramatsu, H., Muramatsu, T. and Suzumura, A. (2008) Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population. Proc. Natl. Acad. Sci. USA. 105, 3915-3920. [PMID: 18319343]
Flatscher-Bader, T. and Wilce, P. A. (2008) Impact of alcohol abuse on protein expression of midkine and excitatory amino acid transporter 1 in the human prefrontal cortex. Alcohol Clin. Exp. Res. 32, 1849-1858. [PMID: 18657127]
Jin, Z., Lahat, G., Korchin, B., Nguyen, T., Zhu, Q. S., Wang, X., Lazar, A. J., Trent, J., Pollack, R. E. and Lev, D.(2008) Midkine enhances soft-tissue sarcoma growth: a possible novel therapeutic target. Clin Cancer Res. 14, 5033-5042. [18698021]
Mashima, T., Sato, S., Sugimoto, Y., Tsuruo, T. and Seimiya, H. (2009) Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions. Oncogene 28, 9-19. [PMID: 18806831]
Ohgake, S., Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Koizumi, H., Fujisaki, M., Kanahara, N., Matsuda, S., Sutoh, C., Matsuzawa, D., Muramatsu, H., Muramatsu, T. and Iyo, M. (2009) Dopaminergic hypofunctions and prepulse inhibition deficits in mice lacking midkine. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 541-546. [PMID: 19217924]
Sakakima, H., Yoshida, Y., Yamazaki, Y., Matsuda, F., Ikutomo, M., Ijiri, K., Muramatsu, H., Muramatsu, T. and Kadomatsu, K. (2009) Disruption of the midkine gene (Mdk) delays degeneration and regeneration in injured peripheral nerve. J. Neurosci. Res. 87, 2908-2915. [PMID: 19437545]
Hobo, A., Yuzawa, Y., Kosugi, T., Kato, N., Asai, N., Sato, W., Maruyama, S., Ito, Y., Kobori, H., Ikematsu, S., Nishiyama, A., Matsuo, S. and Kadomatsu, K. (2009) The growth factor midkine regulates the renin-angiotensin system in mice. J. Clin. Invest. 119, 1616-1625. [PMID: 19451697]
Ibusuki, M., Fujimori, H., Yamamoto, Y., Ota, K., Ueda, M., Shinriki, S., Taketomi, M., Sakuma, S., Shinohara, M., Iwase, H. and Ando, Y. (2009) Midkine in plasma as a novel breast cancer marker. Cancer Sci. 100, 1735-1739. [PMID19538527]
Helleboid-Chapman, A., Nowak, M., Helleboid, S., Moitrot, E., Rommens, C., Dehondt, H., Helliot, L., Drobecq, H., Fruchart-Najib, J. and Fruchart, J. C. (2009) Apolipoprotein A-V modulates insulin secretion in pancreatic beta-cells through its interaction with midkine. Cell. Physiol. Biochem. 24, 451-460. [PMID 19910685]
Calinescu, A. A., Raymond, P. A. and Hitchcock, P. F. (2009) Midkine expression is regulated by the circadian clock in the retina of the zebrafish. Vis. Neurosci. 26, 495-501. [PMID: 19860997]
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Kim, Y. B., Ryu, J. K., Lee, H. J., Lim, I. J., Park, D., Lee, M. C. and Kim, S. U. (2010) Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus. BMC Neurosci. 11, 42. [PMID: 20346117]
Matsui, T., Ichihara-Tanaka, K., Lan, C., Muramatsu, H., Kondou, T., Hirose, C., Sakuma, S. and Muramatsu, T. (2010) Midkine inhibitors: application of a simple assay procedure to screening of inhibitory compounds. Int. Arch. Med. 3,12. [PMID: 20565917]
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Muramatsu, H., Yokoi, K., Chen, L., Ichihara-Tanaka, K., Kimura, T. and Muramatsu ,T. (2011) Midkine as a factor to counteract the deposition of amyloid β-peptide plaques: in vitro analysis and examination in knockout mice. Int. Arch. Med. 4,1. [PMID: 21223602]
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Frick, I.M., Nordin, S.L., Baumgarten, M., Mörgelin, M., Sørensen, O.E., Olin, A.I., and Egesten, A. (2011) Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes. J. Immunol. 15, 4300-4309. [PMID: 21918193]
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Zhao, G., Nie, Y., Lv, M., He, L., Wang, T., and Hou, Y. (2012) ERβ-Mediated Estradiol enhancese epithelial mesenchymal transition of lung adenocarcinoma through increasing transcription of midkine. Mol. Endocrinol. 26, 1304-1315. [PMID: 22669742]
Sonobe, Y., Li, H., Jin, S., Kishida, S., Kadomatsu, K., Takeuchi, H., Mizuno, T., and Suzumura, A. (2012) Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells. J. Immunol. 188, 2602-2611. [ PMID: 22323540]
Shen, W., Park, B.W., Toms, D., and Li, J. (2012) Midkine promotes proliferation of primordial germ cells by inhibiting the expression of the deleted in azoospermia-like gene. Endocrinology 153, 3482-3492. [PMID: 22564978]
Cohen, S., Shoshana, O. Y., Zelman-Toister, E., Maharshak, N., Binsky-Ehrenreich, I., Gordin, M., Hazan-Halevy, I., Herishanu, Y., Shvidel, L., Haran, M., Leng, L., Bucala, R., Harroch, S., and Shachar, I. (2012) The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74. J. Immunol. 188, 259-269. [PMID: 22140262]
Weckbach, L. T., Groesser, .L, Borgolte, J., Pagel, J.I., Pogoda, F., Schymeinsky, J., Mueller-Hoecker, J., Shakibaei, M., Muramatsu, T., Deindl, E., and Walzog, B. (2012) Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis. Am. J. Physiol. Heart Circ. Physiol., in press. [PMID: 22707563]
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Zhang, H., Okamoto, M., Panzhinskiy, E., Zawada, W.M., and Das, M. (2014) PKCδ/midkine pathway drives hypoxia-induced proliferation and differentiation of human lung epithelial cells. Am. J. Physiol. Cell. Physiol. 306, C648-658. [PMID:24500281]
Fan, N., Sun, H., Wang, Y., Zhang, L., Xia, Z., Peng, L., Hou, Y., Shen, W., Liu, R., and Peng, Y. (2014) Midkine, a potential link between obesity and insulin resistance. PLoS One. 9, e88299. [PMID:24516630]
Vicente-Rodríguez, M., Pérez-García, C., Haro. M., Ramos, M.P., and Herradón, G. (2014) Genetic inactivation of midkine modulates behavioural responses to ethanol possibly by enhancing GABA(A) receptor sensitivity to GABA(A) acting drugs. Behav. Brain Res. 274, 258-263. [PMID:25149366]
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Luo, J., Wang, X., Xia, Z., Yang, L., Ding, Z., Chen, S., Lai, B., and Zhang, N. (2015) Transcriptional factor specificity protein 1 (SP1) promotes the proliferation of glioma cells by up-regulating midkine (MDK). Mol. Biol. Cell. 26, 430-439. [PMID:25428991]
Dianat, N., Le Viet, B., Gobbo, E., Auger, N., Bièche, I., Bennaceur-Griscelli, A., and Griscelli, F. (2015) Midkine lacking its last 40 amino acids acts on endothelial and neuroblastoma tumor cells and inhibits tumor development. Mol. Cancer Ther. 14, 213-224. [PMID:25492619]
Zhang, R., Pan, Y., Fanelli, V., Wu, S., Luo, A. A., Islam, D., Han, B., Mao, P., Ghazarian, M., Zeng, W., Spieth, P. M., Wang, D., Khang, J., Mo, H., Liu, X., Uhlig, S., Liu, M., Laffey, J., Slutsky, A. S., Li, Y., and Zhang, H. (2015) Mechanical stress and the induction of lung fibrosis via the midkine signaling pathway. Am. J. Respir. Crit. Care Med. 192, 315-323. [PMID:25945397]
He, D., Chen, H., Muramatsu, H., and Lasek, A. W. (2015) Ethanol activates midkine and anaplastic lymphoma kinase signaling in neuroblastoma cells and in the brain. J. Neurochem. 135, 508-521. [PMID:26206265]
Haffner-Luntzer, M., Heilmann, A., Rapp, A.E., Roessler, R., Schinke, T., Amling, M., Ignatius, A., and Liedert, A. (2016) Antagonizing midkine accelerates fracture healing in mice by enhanced bone formation in the fracture callus. Br. J. Pharmacol. in press. [PMID:27111560]

Edited by　 T. Muramatsu